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doi:10.3390/molecules20047396

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Further analyses of data from five major ARDS trialsARMA, ALVEOLI, FACTT, SAILS, and HARP-2along with two prospective observational cohorts, including over 4,000 patients, consistently showed that patients with the hyperinflammatory subphenotype had higher mortality rates compared to those with the hypoinflammatory subphenotype [73,74,75]