The 2024 fusion-peptide work exists precisely because researchers recognized that native DSIPs delivery to the brain is the bottleneck, and engineered around it by fusing DSIP to a blood-brain-barrier-crossing TAT transduction domain (sequence GGGGYGRKKRRQRRR) via flexible GGGGS linkers, expressed and secreted from Pichia pastoris
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Incretin-based therapies have been associated with a body weight (BW) reduction of 5% in at least half of patients in most randomized controlled trials (RCT) and real-world studies (RWS)
A mean classification error across all samples was subsequently calculated