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Lancet 376:595605 Apovian CM, Aronne L, Rubino D et al (2013) A randomized, phase 3 trial of Naltrexone sr/bupropion SR on weight and obesity-related risk factors (COR-II)
Some people ask why not dose even less frequently if the half-life is seven days
For example, when an injectable and pH-sensitive peptide hydrogel loaded with methotrexate and bismuthene nanosheet/polyethyleneimine (BiNS/PEI) reduced macrophage cytokine secretion and eliminated synovial fibroblasts, a multi-target therapeutic effect was achieved (104)
A number of studies have shown beneficial effects of GLP-1-based interventions on measures affecting cardiovascular pathologies such as blood pressure, body weight and lipid metabolism that are thought to be exerted independent of GLP-1 analogues effects on glycemic control 8,9 and the effects on markers of atherosclerosis are also reported 10,11,12
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