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Melatonin is synthesized in the pineal gland through the activation of two key enzymes: AANAT (arylalkylamine N-acetyltransferase) pCREB (phosphorylated cAMP response element-binding protein) In rat pinealocytes, Epitalon was shown to upregulate both AANAT and pCREB, suggesting a direct enzymatic stimulation of melatonin biosynthesis [56]
Ashina, M
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J Control Release 348:115126 Liu Z, Bu R, Zhao L, Liu L, Dong N et al (2021) Hydrogel-containing PLGA microspheres of palonosetron hydrochloride for achieving dual-depot sustained release
