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5-oxoprolinase deficiency and glutathione synthetase deficiency share some clinical and biochemical features (36)

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Data analysed by one-way ANOVA, multiple comparison, Bonferroni post hoc test ( a - c and g - k ) and two-way repeated measures ANOVA to assess main effects of treatment ( e and f )

Between-group analysis revealed a significant reduction in CRP ( p : 0.001) and serum chloride ( p : 0.032), an increase in serum albumin ( p : 0.036) and platelet ( p : 0.004) significantly, and an increase in SOD marginally ( p : 0.073)

In addition, to determine the percentage distribution of reacted RT between GSH and protein thiols, we treated HeLa cells with RT and lysed the cells using trichloroacetic acid to separate proteins from small molecules (Fig