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References References Selective and membranepermeable small molecule inhibitors of NNMT Roles of Nicotinamide NMethyltransferase in Obesity and Type 2 Diabetes Nicotinamide Nmethyltransferase inhibition mimics and boosts exercisemediated improvements in muscle function in aged mice Reduced calorie diet combined with NNMT inhibition establishes a healthier gut microbiome in obese mice Kraus et al

Side effects are rare and usually mild (slight injection-site soreness)

Despite this, we still have no direct evidence that lowering Lp(a) levels reduces cardiovascular risk: the Lp(a) hypothesis is yet to be proven

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Cancer Cell 24 , 450465 (2013)