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This is because ice crystal formation and repeated freeze-thaw cycles can cause aggregation, denaturation, or structural disruption
Phase-2 trials did report some benefits of ipamorelin in the condition, but the results were not deemed clinically significant within 7-10 days of therapy, leading to discontinuation of trials [9, 10]
Regular follow-up with a clinician, including testing for kidney function, and discontinuation of the drug if signs of toxicity develop are advised (Curiel 2013)
In men, excess adiposity is associated with decreased testosterone, increased estradiol from aromatization, impaired spermatogenesis, and erectile dysfunction
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