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Notably, the BoNT/X H N domain has been shown to effectively deliver a range of protein cargos with minimal toxicity 28
Similarly, ONCOS-102, an engineered adenovirus expressing GM-CSF, has been tested with pembrolizumab in advanced melanoma (NCT03003676), aiming to activate dendritic cells and potentiate T-cellmediated responses
Rogers and Fox 2004) and can promote experimental carcinogenesis of the liver (NTP Toxicology and Carcinogenesis Studies of Theophylline 1998
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