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Key points Obesity is a risk factor for developing osteoarthritis (OA), gout, rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA), and is associated with higher disease activity and/or severity, and worse response to common treatments

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One smoothie pack can still be the right size

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Over the counter GLP-1 supplements use ingredients such as ashwagandha, green tea extract, berberine, chromium, and saffron

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Treatment with drugs that includes L-carnitine, hydroxocobalamin, biotin, sodium phenylbutyrate (nitrogen scavenger to reduce serum ammonia levels), L-arginine, and N-carbamylglutamate should be instituted

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Some compounding pharmacies offer intermediate doses that allow for smaller increments between levels

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