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10.1038/s41418-023-01199-w 67 LiuP

J., Rosenstock, J., Perez Manghi, F

Oral pills approved by the FDA in early 2026 are showing strong effectiveness

Leptin sensitivity, for example, seems to increase as weight decreases, so that the brain is getting sharper indications of energy reserves

GLP-1 medications act on both upstream and downstream drivers of neurodegeneration, improving insulin sensitivity, vascular function, and mitochondrial efficiency while also influencing amyloid, tau, neuroinflammation, and synaptic health