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Interestingly, GLP-1R pharmacological agonists biased away from -arrestin recruitment exhibit improvements in signalling duration and capacity for sustained insulin secretion (Jones et al., 2018), while agonist-induced cyclic AMP (cAMP) / protein kinase A (PKA) signalling is prolonged in -arrestin 1/2 double-knockout (KO) HEK293 cells (Jones et al., 2021), suggesting that -arrestin deficiency favours sustained GLP-1R action
Representations of lipid nanoparticles using large language models for transfection efficiency prediction
This is because an unhealthy gut cannot properly absorb vitamin B12
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