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By these standards, such drugs are new, and their very long-term effects on the body are not yet known

Chemical biology of homocysteine thiolactone and related metabolites

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Retatrutide for type 2 diabetes: Phase 2 trial results (36-week study, HbA1c reductions, weight loss) New England Journal of Medicine (2023) Jastreboff AM, et al

This is part of how it promotes satiety, but it also means food moves through the stomach and intestines more slowly than normal