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In contrast to antipsychotic agents, which predominantly alleviate positive symptoms of schizophrenia, PDE1B and PDE10A inhibitors hold promise in addressing the broader symptomatology, including the negative and cognitive symptoms that remain inadequately managed by current therapies (Sadeghi et al., 2023)

Transient breathing discomfort or mild bronchospasm reported in some individuals, particularly those with asthma or sensitive airways

However, it is said to be less painful than even CoolSculpting, which is easily tolerated by most patients

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