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Lastly, this study highlighted the decrease in brain inflammation and marked increase in glial cell activation [61], again illustrating the anti-inflammatory and neuroprotective properties of GLP-1

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It has been found that after knocking out the DPP4 gene in rats, metformin could still dose-dependently increase GLP-1 concentrations (Yasuda et al., 2002)

At the core of autoimmune pathogenesis lies immune dysregulation, particularly failure of peripheral tolerance maintained by regulatory T cells (Tregs)

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