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The primary central effects of FGF19 result in the normalization of glucose metabolism in obese subjects, enhancement in glucose tolerance and insulin sensitivity in the liver and skeletal muscle, and increased insulin secretion

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By splitting the dose, patients may experience fewer peaks of nausea and fewer troughs of returning hunger, though this must only be done under medical supervision

2 Methodology A structured literature search was conducted using PubMed/MEDLINE and Google Scholar, with the Boolean search string: (GLP-1 receptor agonist OR GLP-1RA) AND (multifaceted roles OR pleiotropic effects)

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