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The observation that the metabolic effects of GLP-1RA/tesaglitazar depend on functional GLP-1R in vivo align with our in vitro demonstration that GLP-1RA/tesaglitazar fails to induce PPAR/RXR heterodimerization in the absence of GLP-1R (Fig
S., Teeter, S
Building on these recent studies, the growing availability of structural insights is expected to substantially advance drug discovery efforts targeting the ghrelin receptor
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