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Four main routes: Passive diffusion through the cell membrane Active transport Facilitated passive diffusion via small pores Pinocytosis where a drug is engulphed and brought into the cell Factors that influence absorption from the GI tract: Some factors may affect absorption, these include: Particle size large molecules are often not absorbed Chemical breakdown e.g
Huston, A
2025;9(9):bvaf119
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This revealed that a peripheral loop in the N-terminal domain of CRBN (amino acids 146153) is brought closer to the ENL YEATS domain than in any other structure (median root-mean-square deviation (r.m.s.d.) = 3.8 ) and contributes to the high degree of shape complementarity between CRBN and ENL (Fig
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