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Int J Mol Sci 2020, 21
Research Insights: This is also one of the few areas of nutrition with large-scale clinical trial data behind it
Excessive production of RAGE on brain microvascular endothelial cells increases A transport into the brain tissue and decreases its removal, leading to the accumulation of A in the brain tissue, which in turn triggers a series of neurodegenerative pathological changes, such as the formation of amyloid plaques, the formation of neurofibrillary tangles, and the loss of neurons (23)
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