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Less than four weeks of stagnation rarely qualifies as a true plateau

IGF-1 decreased miR-143 expression and increased IGF1R expression in PC-3 and DU145 cells, and made these cell lines more resistant to docetaxel treatment, suggesting that IGF-1 levels are also involved in resistance to treatment in PCa (54)

The transition into a post-reproductive state, such as menopause or estropause, is associated with the development of a systemic pro-oxidant environment characterized by increased reactive oxygen species and diminished antioxidant defenses [146]