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Freezing can cause microscopic cracks in the glass vial, potentially compromising the seal
Industry Response: The compounding pharmacy industry, medical practitioners, and patient advocacy groups pushed back against the Category 2 classification, arguing that the safety data did not support such a restrictive designation
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Sikiric et al., 2020b), along with suggested significance of NO-synthase and the basal formation of NO in stomach mucosa, greater than that seen in other tissues (Whittle et al., 1992), BPC 157 exhibits a general, effective competing with both L-arginine analogs (i.e., L-NAME) and L-arginine (Sikiric et al., 2014)
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