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In the context of glutamine depletion or inhibition of glutamine transport, in conjunction with ICD-inducing chemotherapeutic agents, a synergistic activation of IFN- occurs, leading to CD8 T-cell recruitment and an inhibition of cancer cell growth via the OTUD4/LDHA axis [97]
Metformin enhances anti-mycobacterial responses by educating CD8 + T-cell immunometabolic circuits
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