As much as I enjoyed reading Outlive , and as strongly as I believed health care was ripe for a Medicine 3.0 revolution, I also knew that sometimes disrupting a status quo could backfire
Guanylate Cyclase-C Agonists Examples: Linaclotide, Plecanatide Mechanism: cGMP activates CFTR channels intestinal fluid secretion accelerate transit Uses: Chronic constipation, IBS-C Adverse Effects: Diarrhea, abdominal pain Bulk-forming safest, long-term use Osmotic acute or hepatic encephalopathy (lactulose) Stimulants short-term only Stool softeners post-surgery, hemorrhoids Lubricants avoid long-term Chloride channel activators & GC-C agonists newer agents for chronic constipation Mnemonic for Laxatives: BOSS-LC B Bulk-forming O Osmotic S Stimulant S Stool softeners L Lubricant C Chloride channel activators / cGMP agonists Laxative Types and Mechanisms for Constipation Relief Laxatives Laxatives are drugs that promote bowel movements to relieve constipation or clear the bowel before procedures
The study authors, from Johns Hopkins Medicine, linked levothyroxine use to a greater loss of bone mass and bone density over six years even in older adults with normal thyroid function
If PCAC recommends a peptide for inclusion and the FDA ultimately adds it, compounding becomes lawful under Section 503A
If the pen allows for splitting the dose, then use the prefilled pens only