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As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19

Restaino RM, Deo SH, Parrish AR, Fadel PJ, Padilla J

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doi: 10.3389/fnagi.2022.1059017 Received 30 September 2022 Accepted 12 December 2022 Published 06 January 2023 Volume 14 - 2022 Edited by Panteleimon Giannakopoulos, Universit de Genve, Switzerland Reviewed by Aarti Mishra, AbbVie, United States