Contact your GP if: You have been found to have elevated B12 levels and have not received an explanation or follow-up plan You are taking high-dose B12 supplements without medical supervision You develop new symptoms whilst taking B12 supplements, particularly skin changes, persistent headaches, or gastrointestinal symptoms You have risk factors for liver disease (alcohol excess, viral hepatitis, obesity) and have elevated B12 You experience unexplained weight loss, night sweats, or persistent fatigue alongside elevated B12 Seek urgent medical attention if you experience: Jaundice (yellowing of skin or eyes) Severe abdominal pain or swelling Unexplained bruising or bleeding Confusion or altered consciousness Severe, persistent vomiting These symptoms may indicate serious underlying conditions such as acute liver failure, haematological emergencies, or other critical illness requiring immediate assessment

Semaglutide drug is used for weight loss and is sometimes combined with vitamin B12 to improve results and energy levels
Natural: Synthetic cyanocobalamin requires conversion in the liver to become active, which means some people may not absorb it efficiently
Its hard to say exactly how long B12 shots last in the fridge compared with a cabinet, but this should help extend the shelf life of your injectable B12 after opening
Injecting it as a shot is also recommended for pernicious anemia in which case it treats low red blood cell counts due to poor absorption of the vitamin