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Notably, the benefits appear to be more pronounced in patients with established ASCVD, reinforcing the importance of GLP-1 RAs as a cardioprotective intervention
They may recommend laboratory testing to evaluate for anemia, thyroid dysfunction, vitamin deficiencies (particularly B12 if you also take metformin, vitamin D, and iron), or other metabolic abnormalities
They should also not make unproven claims about its efficacy or safety
In the hyperglycemic clamp, it was confirmed that the suppression of hepatic glucose output is not necessarily due to glucagon-induced glycogen depletion, as was observed in the g1437 group but not in cotadutide-treated mice
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