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Commonly reported side effects in research settings include: Nausea, particularly during dose-escalation phases

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An imbalance or excess of methionine compared with other amino acids in food may have serious implications to human health and healthy ageing as discussed in a personal view from Neubauer and Landecker (2021)

[2] After the promising results from the 12-week trial, a more extended 24-week trial was conducted with a larger group of 536 subjects