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These compounds have demonstrated analgesic, anti-inflammatory, and antioxidants properties through inhibition of the NLRP3 inflammasome and modulation of pain signaling pathways

It can be taken any time of day, with or without food

It is not FDA-approved, and its human evidence base is older, limited, and conflicting

Lifestyle elements such as diet, physical activity, and sleep patterns play a role on the development and management of both conditions, highlighting the need for integrated treatment strategies

After 24 weeks of treatment, significant reductions in neuropathy symptom and disability scores and in neurophysiological parameters were seen in both groups, with no difference between the two drugs safety-wise