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Both semaglutide and tirzepatide slow gastric emptying as part of their mechanism

For patients with type 2 diabetes, Semaglutide GLP-1 injections help regulate insulin release in response to food, lower the amount of glucagon (a hormone that raises blood sugar levels), and slow down gastric emptying to enhance feelings of fullness

Yin HZ, Sensi SL, Ogoshi F, Weiss JH

Real-world observations from clinical practices using semaglutide echo the trial findings: fatigue emerges during dose escalation phases and commonly resolves within one to three weeks of reaching a stable maintenance dose