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The conflicting observations between human and animal studies determining how various hormones actions regulate metabolic homeostasis, especially GLP-1, demonstrate that the findings from animal studies may have reduced clinical implications

Our own group previously hypothesized a direct effect of GLP-1RAs on sino-atrial cells (106), after exclusion of other potential causes

In e and f , these residues are buried, and thus are not visible, while in g , exposure of these residues provides space for the G protein to bind

At lower doses, appetite suppression and weight reduction may occur

In 1987, GLP-1 (736) was recognized as a physiological incretin in the studies of Kreymann et al