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The analysis further noted that the safety advantage of the combination of GLP-1 RA & Metformin is mechanistically rooted in complementary pathways where metformin's AMPK-mediated suppression of hepatic gluconeogenesis and enhancement of peripheral glucose uptake, alongside GLP-1 RA's glucose-dependent insulin secretion and modulation of gastric motility, together prevent excessive gastric emptying delay that drives GI intolerance
Vitamin B12 shots are given to prevent or treat vitamin B12 deficiency
Beyond glucose and weight control, GLP-1s are increasingly used in patients with elevated cardiovascular risk, as clinical evidence shows benefits in reducing major cardiovascular events in people with diabetes or obesity, she says
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