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The discovery of its biological activity came from an unexpected observation: serum from young donors (age 20-25) could stimulate aged liver tissue to synthesize proteins at a rate characteristic of younger tissue, while serum from older donors (age 60-80) could not
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doi:10.1016/S0891-5849(00)00431-7
This is situated between aspartic acid (position 2) and lysine (position 7)
Pratley RE, Aroda VR, Lingvay I, et al
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