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Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk
A 2014 study involving 976 subjects reported similar results (2)
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Annals of Neurology 53 (Suppl 3): S39-47
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