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The active semaglutide peptide has partially degraded, meaning each dose delivers less medication than the label indicates
doi:10.1042/BST20120066
Together with the inward movement of the extracellular part of TM5, they push the N-terminus of GLP-2 away from TM5 to reside closely with TM3, where H268 3.37b contributes a hydrogen bond to stabilize the conformation (Supplementary information, Fig
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