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GLP-1 receptor agonists work by mimicking a natural hormone that helps regulate appetite, slow digestion, and improve blood sugar control
Tirzepatide titration may continue as follows: Week 8: 7.5 mg weekly (if 5 mg was well-tolerated) Week 12: 10 mg weekly (for patients who need additional appetite suppression) Week 16: Up to 12.5 mg or 15 mg (maximum doses, used selectively) Ipamorelin adjustments: If well-tolerated at 200 mcg, may increase to 250 to 300 mcg daily Some physicians add a second daily dose (morning, fasted) for enhanced GH support If water retention or joint stiffness develops, dose may be reduced Labs at the 8-week mark should include IGF-1, thorough metabolic panel, HbA1c, and lipids
May improve exercise performance L-carnitine may support exercise performance because it may help preserve muscle glycogen, promote fat use and spare the use of amino acids as energy sources, allowing them to be used to make new protein instead
If not, our team will provide a simple referral for labs through your primary care provider
Medically reviewed by Patricia Hartke, Pharm.D., BCPS Last update: April 22, 2026 Est
