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Vegetarians and vegans Vitamin B12 recommendations do not differ for people following a plant-based diet

MTHFR gene mutation can impact B vitamin bioavailability

Thats the difference between biological plausibility and clinical validation

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A simpler surrogate is the acetaminophen (paracetamol) absorption test : because acetaminophen is negligibly absorbed by the stomach but rapidly absorbed by the small intestine, the rise in its plasma concentration tracks the rate of gastric emptying a convenient method often embedded in early-phase metabolic studies