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Unfortunately, many patients regain weight after discontinuation, so these medications are currently seen as a long-term therapy
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The prolonged half-life ensures that therapeutic drug concentrations remain stable between doses, allowing continuous engagement with GLP-1, GIP, and glucagon receptors throughout the dosing interval
Zhang, X., Wu, F
The mechanism-based rationale for concerns is strong, however, especially if applied to settings in which these peptides are used on a long-term basis [2, 24]
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