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The GMP compliant production of [ 68 Ga]Ga-DO3A-Tuna-2 and [ 68 Ga]Ga-DO3A-Exendin-4 was developed and conducted on an automated synthesizer (Modular Lab Pharm Tracer, Eckert & Ziegler, Germany) using disposable cassette system
Vigorous shaking generates foam and shear forces that can denature or aggregate the peptide, reducing potency
Its longer structure helps it stay stable in the body and bind more effectively to GHRH receptors than natural GHRH does
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