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NNMT Selectivity Appetite Change Powder Stability 5-Amino-1MQ shows high selectivity for NNMT over other methyltransferases, reducing off-target effects
What they found: Oral AOD-9604 reduced body fat by 18 to 22 % vs placebo, comparable to injection administration No changes in total body weight (because lean mass rose slightly) Decrease in plasma triglycerides by 30 % Decrease in resting free fatty acids (paradoxically, mobilization of fat from depots into oxidation) No GI side effects Why it matters: It suggested that AOD-9604 could work orally , a rare property for a peptide
Similarly, certain foods or medications that interfere with B-vitamin absorption arent a concern since absorption isnt reliant on the gut here, but overall health habits matter
Despite the warning label, individuals continue to use them and the individual does not know what they are getting all the time. There is some research on the following peptide injections: Body Protection Compound-157 (BPC-157) Initial and pre-clinical-trial research suggest BPC-157 may promote musculoskeletal healing, which could explain its popularity among athletes (although it is banned in professional sports)
The lack of FDA approval also means that definitive safety and efficacy trials are still forthcoming
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