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These results were expected given the previously reported increased excitability of MCs, due to an increase in firing frequency, after GLP-1 or Ex4 addition in OB slices 17
J., Chen, Z., Rosen, N
These drugs are part of a class known as GLP-1 receptor agonists, which have shown promise in aiding weight loss
GLP-1 exerts several key physiologic effects: Increases glucose-dependent insulin secretion Suppresses inappropriate glucagon release Delays gastric emptying Promotes satiety and reduces appetite Pharmacologic GLP-1 receptor agonists, including semaglutide, liraglutide, and tirzepatide, are engineered to resist DPP-4 degradation, allowing them to persist for hours to days
