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In the validation stage, an independent cohort (Cohort 2) comprising four age- and sex-matched groups (30 RBD-PD patients, 14 non-RBD-PD patients, 30 iRBD patients and 30 Ctrl subjects, all of whom underwent gold-standard video polysomnography (vPSG) assessment for the confirmation of RBD status) was included
Zhu (Tsinghua University) for providing the pINDUCER hygro, pINDUCER hygro-TPNOX-Flag and pINDUCER hygro-mitoTPNOX-Flag plasmids
The magnitude of blood pressure reduction is clinically meaningful and exceeds that typically achieved with single antihypertensive medications
Other small molecule inhibitors have also been reported, including those derived from amino adenosine and other nicotinamide-related compounds 206,207,208
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