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Fatigue was slightly more likely with semaglutide, while injection site reactions were reported more with tirzepatide

GLP-1 activation slows gastric emptying, which is part of how these compounds reduce appetite, and that same slowing is what produces nausea when it changes too abruptly

The injections are not really recommended for weight-loss use outside of medical weight-loss programs

Close monitoring and alternative diabetes management strategies are essential to prevent hyperglycaemia and complications

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