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Their half-lives are comparable (a few minutes in the periphery, prolonged action in the central nervous system)
Keep consecutive injections at least one inch apart from any previous site, and avoid any area that is bruised, scarred, inflamed, or still tender from a previous dose
Autoantibodies and interferon- present in SLE sera enhance binding of the transcriptional repressor CREM to Gpx4 promoter, which leads to suppressed expression of GPX4 and subsequent elevation of lipid-ROS
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