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Sirtuin activation Sirtuins (SIRT1-7) are NAD+-dependent enzymes that regulate gene expression, mitochondrial biogenesis, inflammation, and stress responses

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2013 and re-evaluated in FDA's 2024 PCAC briefing

Users of any of these compounds should discuss their use with a physician who can monitor for adverse effects and advise on contraindications including for BPC-157, which carries an unresolved angiogenesis risk that is particularly relevant for individuals with active or suspected cancer