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In addition, the urinary metabolite 6-sulfatoxymelatonin (aMT6) has been proposed as biomarker for antidepressant responders, by revealing whether the blockage of noradrenaline uptake has taken place within 24 h from the first antidepressant dose

If sterile technique was compromised, bacterial growth may be present even in a clear solution, especially in the early stages before the colony is large enough to cause visible turbidity

The depletion of NADPH directly leads to a decrease in GSH levels, inactivates GPx4, and prevents the clearance of intracellular LPO, eventually causing the accumulation of LPO