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Patients should continue with lifestyle modifications, including a balanced diet and regular physical activity, to maximise cardiovascular health alongside pharmacological treatment
Tolerance to the appetite-suppressing effect A small number of patients report that the appetite-suppressing effect of Mounjaro seems to diminish over time
It has not received FDA approval and remains a research compound in the United States and most Western markets
Clinical trials have consistently demonstrated a weight reduction of 20% or more, alongside improvements in blood pressure, glucose control, and cardiovascular health
However, under T2D conditions, the endothelium expresses cell adhesion molecules that adhere to leukocytes [42]
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