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Many patients report feeling increased alertness and reduced fatigue within hours of injection
Arthroscopy 14 , 840843 (1998)
The first reaction is catalyzed by tryptophan hydroxylase (TPH-1), which requires L-tryptophan, tetrahydrobiopterin (BH4), and O 2 as co-substrates, and has ferrous ion (Fe 2+ ) as an activator
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