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A natural moisturizer thats also in our skin A super common, safe, effective and cheap molecule used for more than 50 years Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40% High-glycerin moisturizers are awesome for treating severely dry skin An easy-to-formulate, commonly used, nice to have ingredient thats also called pro-vitamin B5
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What they found (summary): MC1R: melanogenesis, pigmentation, anti-inflammation MC2R: ACTH receptor in the adrenals (Melanotan II does not act) MC3R: energy, cardiovascular function, anti-inflammation MC4R: appetite (central control), sexual function, autonomic regulation MC5R: exocrine glands (sebaceous, lacrimal, salivary) Mutations in MC4R are the most common monogenic cause of obesity in humans Why it matters: Cones review article is the reference article for all of melanocortin pharmacology
Cong, et al., 'Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide', Cell Discov
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