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Exclusion criteria included any pharmacological treatment of the gastrointestinal tract, systemic antibiotics within the last 3 months, probiotics or low-FODMAP-diet within the last 3 weeks, vegan or vegetarian diet, regular use of analgesics, pregnancy, prior gastrointestinal surgery apart from appendectomy (16)
Pre-clinical and Phase 2 data suggest this translates into lipid-lowering, hepatic-fat-reducing, and energy-expenditure effects that tirzepatide, by design, lacks
After adjustment for baseline differences between groups, semaglutide was associated with greater weight reduction and more pronounced LDL cholesterol lowering, whereas improvements in HbA1c were broadly comparable between treatments
Many patients who relied on these more affordable medications will now have to transition to FDA-approved formulas that may be more expensive or difficult to access due to insurance limitations
