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Newly synthesized Ras must reach the Golgi and undergo S-palmitoylation to acquire strong hydrophobicity before its packaging into transport vesicles and delivery to the plasma membrane
Therefore, with a well selected population that would diminish the 95% confidence interval of relative risk of cardiovascular disease, we suggest that there might be an increased cardiovascular risk in the MTHFR TT mutants when folate status is low
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