The following is a comparison of the incidence rates of gastrointestinal adverse events with semaglutide at different doses from randomized controlled trials: Serious events and warnings: Rare but serious side effects of semaglutide and dulaglutide are: Pancreatitis (inflammation of the pancreas) Changes in vision (worsening diabetic retinopathy) Gallbladder issues (cholecystitis and cholelithiasis) Injection site reactions (redness, inflammation, infection, and scarring) Severe stomachache Suicidal ideation Excessive burping Mood and behaviour changes Hypoglycemia Allergic or hypersensitivity reaction High risk of aspiration (stomach content entering the respiratory tract) during surgical procedures that require anesthesia or sedation GLP-1 medications are contraindicated for patients with a personal or family history of medullary thyroid carcinoma and MEN 2 syndrome (Multiple endocrine neoplasia type 2 syndrome)

Even if one chooses not to take a GLP-1 to manage weight loss, adherence to a Mediterranean-style diet, adequate hydration, and resistance training combined with aerobic exercise is recommended for weight loss and preservation of muscle mass.
However, it is important to note that recent studies on MCT4 inhibition have revealed significant systemic side effects that may limit its clinical translational potential
These contractions stimulate satellite cells, essential for muscle repair and growth, and support hypertrophy and strength
As costs and side effects push many to discontinue use, this emerging post-GLP-1 population is seeking sustainable solutions